Faculty Information

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Joseph Russell Madsen, M.D.

Professional Societies:

• 1976- American Association for the Advancement of Science
• 1985-1989 Congress of Neurological Surgeons, Resident Section
• 1985- American Medical Association
• 1989- Massachusetts Epilepsy Foundation
• 1990- Massachusetts Medical Society
• 1990- New England Neurosurgical Society
• 1990- New York Academy of Sciences
• 1990- Society for Neuroscience
• 1991- Boston Society of Neurology and Psychiatry
• 1991- Research Society of Neurological Surgeons
• 1992- Congress of Neurological Surgeons
• 1992- Society for Neuroscience
• 1994- Hydrocephalus Association
• 1995- American College of Surgeons, Fellow

Teaching/Invited Lectures:

• 1985 Management of Head Injury, CME Course in Emergency Medicine, Massachusetts General Hospital, Dr. P. Gross, Course Director
• 1986 Monoclonal Antibodies in Neurosurgical Research, Review and Update in Neurobiology for Neurosurgeons, Woods Hole, MA. Dr. H. Schmidek, Course Director
• 1986 Seminar leader, Neural Regeneration. Oliver Wendell Holmes Society ("New Pathway"), Harvard Medical School. Dr. E. Furshpan, Course Director
• 1987-1988 Instruction and supervision of medical students rotating in Neurosurgery, Massachusetts General Hospital
• 1988 Monoclonal Antibody Methods in the Study of Regeneration. Neurosurgical Conference, University of Florida, Gainesville FL
• 1989- Lecturer to Core Clinical Clerkship in Surgery, Brigham and Women's Hospital
• 1990- Preceptor in Neurosurgery, Introduction to Clinical Medicine course, Harvard Medical School
• 1990 Cervical Disc Disease and Spondylosis. Review Course in Internal Medicine, Beth Israel Hospital, Boston MA. Dr. C. Fanta, Director
• 1990 Emergency Management of Head Injuries. Department of Emergency Medicine, Cambridge Hospital, Cambridge MA
• 1990 Chiari Malformations: Anesthesia Implications. Department of Anesthesia, Children's Hospital
• 1990 Lecturer to HST-050 (Neuroscience Course). Harvard MIT Program in Health, Science and Technology, Boston MA
• 1991 Neurosurgical Problems in the First Six Months of Life. Pediatric Grand Rounds, Lawrence General Hospital, Lawrence MA
• 1991 Neurosurgical Approach to the Unborn Patient. Neurology Grand Rounds, Beth Israel Hospital, Boston MA
• 1991 Cervical vertebral osteomyelitis, diskitis, and epidural abscess. Weekly Clinical-pathological exercises, Dept. of Pathology, Mass. General Hospital
• 1992 Neurosurgical Approaches to Spasticity. Neurology Grand Rounds, Brigham and Women's Hospital
• 1992 Treatment of Spasticity. Neurosurgery Grand Rounds, Brigham and Women's Hospital
• 1992 Repairing the Child's Brain. Speaker, 1st Annual Justine Brazil Memorial Fund Raising Dinner
• 1992 Injury, Regeneration, and Myelin. Neurosurgery Grand Rounds, Brigham and Women's Hospital
• 1992 Current Management of Neural Tube Defects. Neonatology Grand Rounds, Children's Hospital
• 1993 Trauma Management and Neural Environment. Neurosurgery Grand Rounds, Brigham and Women's Hospital
• 1993 New Approaches in Myelomeningocele Management. Neonatology Grand Rounds, Children's Hospital
• 1994 Emergency Management of Shunt Problems. Emergency Services Conference, Children's Hospital
• 1994 Eosinophilic Granulomas. Neuropathology Conference, Children's Hospital
• 1995 Neurosurgery of the Newborn. Pediatric Grand Rounds, Framingham Union Hospital, Framingham MA
• 1995 Pediatric Epilepsy Surgery: Maps and Myths. Neurology Grand Rounds, Beth Israel Hospital, Boston MA
• 1995 Rhizotomy for Cerebral Palsy. Rehabilitation Services Grand Rounds, Children's Hospital
• 1995 Gapless Growth. Combined Neurosurgery Research Conference, Children's Hospital
• 1995 Hemispherectomy: Techniques and Results, Congress of Neurological Surgeons Seminar
• 1995 Hydrocephalus Beyond the NICU. Newborn Medicine Followup Conference, Children's Hospital
• 1996 Bimechanics of Pediatric Spinal Injuries, AANS Meeting Seminar
• 1996 FK-506 Improvement in Recovery after Spinal Cord Injury: Possible Role of GAP-43 Expression in Calcineurin Effect. Research Society of Neurological Surgeons meeting, Newcastle upon Tyne, England

Research Interests:

• Pharmacological interventions to improve regeneration in spinal cord injury.
• Molecular aspects of neural regeneration and development, including development of glial cells.
• Functional surgery in pediatric neural injury.
• Optical and video image enhancement techniques in neurosurgery.

Bibliography

1. Original Reports:

• Stang PJ, Madsen JR, Mangum MG, Fox DP. Unsaturated carbenes from primary vinyl triflates: competitive addition of isopropylidene to olefins. J Org Chem 1977; 42:1802-1804.
• Mandel MR, Madsen J, Miller AL, Baldessarini RJ. Intoxication associated with lithium and ECT. Am J Psychiat 1981; 137:1197-1199.
• Madsen JR, Campbell A, Baldessarini RJ. Effect of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain. Neuropharmacology 1981; 20:931-939.
• Baldessarini RJ, Campbell A, Madsen J, Herschel M, Finkelstein S, Smith JM, Majocha R, Arana G. Chronopsychopharmacology. Psychopharm Bull 1982; 17:112-113.
• Campbell A, Herschel M, Sommer B, Madsen JR, Cohen BM, Baldessarini RJ. Circadian changes in the distribution and effects of haloperidol in the rat. Neuropharmacology 1982; 211:663-669.
• Madsen JR, Black PMcL, Flynn S, Royal HD. Cerebrospinal fluid anion transport: studies of pertechnetate in unanesthetized sheep. Neurosurgery 1985; 17:778-783.
• Hamilton AJ, Black PMcL, Madsen J, Carr DB. Neuropeptide investigations with an ovine surgical model. Neurosurgery 1986; 18:748-755.
• Madsen JR, Matthew WD. Immunologically defined astrocyte subsets: implications for axonal regeneration after central nervous system injury. Surgical Forum 1987; 37:512-515.
• Madsen JR, Hsu DW, Hedley-Whyte ET, Matthew WD. Expression of X-hapten immunoreactivity by human and rat adenohypophyseal cells. J Neurosurgery 1988; 68:938-946.
• Madsen JR, Matthew WD. Immunoreactivity in pituitary gonadotropes and hypo-thalamic vasopressinergic neurons for the monoclonal antibody INO. J Neuroimmunology 1988; 20:83-91.
• O'Tuoma LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD, Scott RM, Black PMcL, Madsen JR, Goumnerova LC, Sallan SE, Tarbell NJ. 201Tl versus 99mTc-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med 1993; 34:1045-1051.
• Sathi S, Madsen JR, Bauer S, Scott RM. Effect of surgical repair on the neurologic function in infants with lipomeningocele. Pediatr Neurosurg 1993; 19:256-269.
• Logigian EL, Wolinsky JS, Soriano SG, Madsen JR, Scott RM. H reflex studies in cerebral palsy patients undergoing partial dorsal rhizotomy. Muscle & Nerve 1994; 17:539-549.
• Carmant L, O'Tuama LA, Roach PJ, Kramer U, Mikati MA, Riviello JJ, Helmers SL, Madsen JR, Black PM, Lombroso CT. Technetium-99m HmPAO brain SPECT and outcome of hemispherectomy for intractable seizures. Pediatr Neurol 1994; 11:203-207.
• Carmant L, Kramer U, Riviello JJ, Helmers SL, Mikati MA, Madsen JR, Black PMcL, Lombroso CT, Holmes GL. EEG prior to hemispherectomy: correlation with outcome and pathology. Electroencephalography and Clinical Neurophysiology 1995; 94:265-270.
• Soriano SG, Logigian EL, Prahl PA, Scott RM, Madsen JR. Nitrous oxide depresses the H-reflex in children with cerebral palsy. Anesthesia & Analgesia 1995; 80:239-241.
• Adelson PD, Black PMcL, Madsen JR, Kramer U, Rockoff M, Riviello, JJ, Helmers SL, Mikati M, Holmes GL. Use of subdural grids and strip electrodes to identify a seizure focus in children. Pedi Neurosurg 1995; 22:174-180.
• Kramer U, Riviello JJ, Carmant L, Black PMcL, Madsen JR, Helmers SL, Mikati M, Holmes GL. The morbidity of depth and subdural electrodes: children and adolescents versus young adults. Journal of Epilepsy, in press.
• Logigian EL, Shefner J, Soriano SG, Goumnerova L, Scott RM, Madsen JR. The critical importance of stimulus intensity in intraoperative monitoring for selective dorsal rhizotomy (DR). Muscle & Nerve, 1996; 19:415-422.
• Kramer U, Riviello JJ, Carmant L, Black PMcL, Madsen JR, Holmes GL. Clinical characteristics of complex partial seizures: a temporal versus a frontal lobe onset. Arch Neurol, submitted, 1995.
• Carmant L, Carrazana E, Kramer U, Helmers SL, Riviello JJ, Holmes GL, Madsen JR, Black PMcL, Mikati M. Localization of pharyngeal paresthesias as an aura in children with intractable complex partial seizures. Neurology, submitted, 1995.
• Madsen JR, MacDonald P, Irwin N, Rimm IJ, Rossitch E, Stieg PE, Benowitz L. FK-506 improves neurological outcome and increases neuronal expression of GAP-43 after spinal cord injury in rats. Nature Medicine, submitted, 1996.
• Taylor GA, Madsen JR. Hemodynamic response to fontanelle compression in neonatal hydrocephalus: correlation with intracranial pressure and need for shunt placement. Radiology, submitted, 1996.
• Lim C, Blume HW, Black PMcL, Madsen JR, Saper CB. The mossy fiber pathway in the human hippocampal formation: calbindin immunohistochemistry in autopsy tissue in in vitro tracing studies using surgical biopsy tissue. Submitted, 1996.
• Lim C, Mufson EJ, Kordower JH, Blume HW, Black PMcL, Madsen JR, Saper CB. An endfolial fiber pathway in the human hippocampal formation: a myeloarchitectural and tracing study of the dentate hilar region. Submitted, 1996.

2. Case Reports and Reviews:

• Madsen JR, Hedley-Whyte ET. Immunohistochemistry of pituitary adenomas. Neurology Neurosurgery Update Series 1987; 7(24):1-8.
• Heros RC, Madsen JR. Hemodynamic method to predict whether Hunterian ligation of the basilar artery will lead to thrombosis of basilar bifurcation aneurysms: Comment. Neurosurgery 1987; 20:252-253.
• Madsen JR. Neuromethods, volumes 1 and 2 [book review]. Am J Neuroradiology 1987; 8:608.
• Madsen JR, Heros RC. Spinal arteriovenous malformations and spinal claudication: report of two cases. J Neurosurgery 1988; 68:793-797.
• Madsen JR, Heros RC. Giant peripheral aneurysm of the posterior inferior cerebellar artery treated with excision and end-to-end anastomosis. Surg Neurol 1988; 30:140-143.
• Madsen JR, Reidy P. The pediatric neurosurgical patient: a cooperative approach, ed by LP Ivan. [book review]. J Neurosurg 1991; 74:306-307.
• Madsen JR. Spinal tumors in children and adolescents, ed by I Pascual-Castroviejo. [book review]. Surg Neurol 1991; 36:73-74.
• Madsen JR, Rosenberg A. Case records of the Massachusetts General Hospital, case 16-1992: a 27-year-old woman with pain in the neck and shoulder. N Engl J Med 1992; 326:1070-1076.
• Sathi S, Folkerth R, Madsen JR. Cavernous angioma of the posterior fossa dura mimicking a meningioma: case report and review of literature. Surg Neurol 1992; 38:257-260.
• Madsen JR, Scott RM. Chiari malformations, syringomyelia, and intramedullary spinal cord tumors. Curr Opin Neurol Neurosurg 1993; 6:559-563.
• Madsen JR. Epilepsy surgery, ed by HO Luders [book review]. J Epilepsy 1993; 6:131.
• Carmant L, Riviello JJ, Kramer U, Thiele E, Helmers S, Mikati M, Madsen JR, Black PMcL, Holmes GL. Compulsory spitting: an unusual manifestation of temporal lobe epilepsy. Epilepsia, in press.
• Madsen JR, Carmant L, Holmes GL, Black PMcL. Corpus callosotomy in children. Neurosurg Clin N Amer 1995; 6:541-548.
• Madsen JR, Adelson PD, Haglund MM. The future of pediatric epilepsy surgery: Signposts and science. Neurosurg Clin N Amer 1995; 6:589-597.
• Estroff JA, Parad RB, Barnes PD, Madsen JR, Benacerraf BR. Posterior fossa arachnoid cyst: an in utero mimicker of Dandy-Walker malformation. J Ultrasound Med 1995; 14:787-790.

3. Book Chapters:

• Schmidek HH, Madsen JR. Commentary on the transvenous treatment of anteroinferior dural venous fistulae. In: Schmidek HH, Sweet WH, eds. Operative Neurosurgical Techniques: Indications, Methods and Results, 2nd ed. New York: Grune & Stratton, 1988:849-854.
• Madsen JR, Heros RC. Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses. In: Sugita K, Shibuya M, eds. Intracranial Aneurysms and Arteriovenous Malformations: State of the Art. Nagoya, Japan: Nagoya University COOP Press, 1990:277-282.
• Black PM, Madsen J. Chronic increased intracranial pressure. In: Asbury AK, McKhann GM, McDonald WI, eds. Diseases of the Nervous System, 2nd ed. Philadelphia: WB Saunders, 1992:967-977.
• Madsen JR. Astrocytomas of the cerebellum. In: Black PMcL, Schoene WC, Lampson LA, eds. Astrocytomas: Diagnosis, Treatment, and Biology. Boston: Blackwell Scientific Publ, 1993:175-180.
• Rossitch E Jr, Madsen JR. Neurosurgical procedures for the relief of pain in children and adolescents. In: Schechter NL, Berde CB, Yaster M, eds. Pain Management in Infants, Children and Adolescents. Baltimore: Williams & Wilkins, 1993:237-243.

4. Abstracts and Presentations:

• Campbell A, Herschel M, Madsen JR, Baldessarini RJ. Diurnal changes in effects of haloperidol in rats. Neurosci Abst 1980; 6:707.
• Madsen JR, Black PMcL, Royal HD. Pertechnetate as a probe of the anion clearance mechanisms of the brain. Poster Session, American Association of Neurological Surgeons Meeting, 1984.
• Madsen JR, Sandrock AW, Matthew WD. Re-expression of an antigen present in developing CNS by injured and sprouting adult neurons. Open Scientific Session, Congress of Neurological Surgeons, 1986.
• Maxwell M, MacGillivary J, Allegra C, Madsen JR, Black PMcL. Functional transplantation of the pituitary gland. Open Scientific Session, Congress of Neurological Surgeons, 1987.
• Maxwell M, MacGillivary J, Allegra C, Madsen JR, Black PMcL. Transplantation of neonatal rat pituicytes into the third ventricle of hypophysectomized recipients leads to restitution of plasma adenohypophyseal hormone levels. IVth Congress on Pituitary Adenomas, Zurich, 1987.
• Madsen JR, Hsu DW, Hedley-Whyte ET, Matthew WD. Expression of X-hapten immunoreactivity by human and rat adenohypophyseal cells: alterations in tumors and estrogen-induced hyperplasia. American Academy of Neurological Surgery, 1987.
• Heros RC, Madsen JR. Spinal arteriovenous malformations and spinal claudication. Richard Lende Neurosurgical Conference, Snowbird, Utah, 1988.
• Madsen JR, Heros RC. Spinal arteriovenous malformations and spinal claudication: a diagnostic dilemma. New England Neurosurgical Society Meeting, 1988.
• De la Monte SM, Madsen JR. X Hapten immunoreactivity in oligodendrogliomas. Lab Invest 1989; 60:23A.
• Ballantine HT, Madsen R. An interview with Dr. HT Ballantine. Video presentation, Archives Committee of the American Association of Neurological Surgeons, 1989.
• Madsen JR, Heros RC. Giant peripheral aneurysms of the posterior inferior cerebellar artery presenting as cerebellar masses. 2nd International Workshop on Intracranial Aneurysms, Nagoya, Japan, April 1989.
• Madsen JR, Matthew WD. Immunoreactivity for two promotors of neurite outgrowth in pituitary cell subsets. Poster Session, American Association of Neurological Surgeons Meeting, 1990.
• Pearl PL, Carrazana EJ, Holmes GL, Russman BS, Madsen, JR. Psychosis and aggressive behavior after corpus callosotomy. American Epilepsy Society, poster presentation, 1990.
• Madsen JR. Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies. Open Scientific Session, Research Society of Neurological Surgeons Meeting, 1991.
• Madsen JR. Glial surface molecules affecting neurite outgrowth: immunological dissection using monoclonal antibodies. Poster Session, American Association of Neurological Surgeons Meeting, 1992.
• Madsen JR. Immunological approach to putative glial surface molecules affecting neurite outgrowth: changes with normal development and after lesions. Poster session, Congress of Neurological Surgeons Annual Meeting. Washington DC, October 31-November 5, 1992.
• Madsen JR. Glial surface molecules in lesions and regeneration: generation of a panel of monoclonal antibodies. Neurosci Abst 1992; 18:1448, abstr 608.3.
• Kim YC, Black PMcL, Madsen J, Holmes GL. Comparison of surface and intracranial electrode studies in children with temporal lobe seizures. American Epilepsy Society Meeting abstract, 1992.
• Carmant L, Riviello J, Kramer U, Helmers S, Mikati M, Madsen JR, Black PMcL, Holmes GL. SPECT scan findings in the evaluation of hemispherectomy for intractable seizures: A predictor of favorable outcome. Presented at the AEEG Eastern and Central meeting, February 19, 1993.
• Carmant L, Riviello J, Kramer U, Helmers S, Mikati M, Madsen JR, Black PMcL, Holmes GL. EEG patterns in patients undergoing hemispherectomy evaluation. Presented at the AEEG Eastern and Central meeting, February 19, 1993.
• Madsen JR, Scott RM, Goumnerova LC, Wolinsky JS, Logigian EL. The latency test: distinguishing valid reflexes in dorsal rhizotomy surgery. Pediatric Session, American Association of Neurological Surgeons, 1993.
• Goumnerova LC, Sathi S, Scott RM, Madsen JR. Treatment of medulloblastoma with preirradiation chemotherapy: experience at Boston Children's Hospital from 1984 to 1991. Pediatric Session, American Association of Neurological Surgeons, 1993.
• Madsen JR, Weisfeiler O, Benowitz LI. Neurite outgrowth and GAP-43 expression: effects of glial substrate and of monoclonal antibodies recognizing glial cell surface proteins. Soc Neurosci Abstr 1993; 19:626, abstr 262.2.
• Carmant L, O'Tuama LA, Treves S, Kramer U, Holmes GL, Riviello JJ, Helmers SL, Black PMcL, Madsen JR, Mikati M. HMPAO SPECT versus outcomes of hemispherectomy for intractable seizures. Child Neurology Society Meeting abstract, 1993.
• Black P. Discharge morphology and propagation patterns in temporal lobe epilepsy in children and adolescents: effects of age. American Epilepsy Society Meeting abstract, 1993.
• Carmant L, Riviello J, Kramer U, Helmers S, Mikati M, Madsen JR, Black P, Holmes G. EEG Patterns in patients undergoing hemispherectomy correlation with outcome and pathology. Epilepsia, 1993.
• Kramer U, Riviello J, Carmant L, Black P, Madsen J, Mikati M, Helmers S, Holmes GL. Clinical characteristics of complex partial seizures: A temporal versus a frontal focus. Epilepsia, 1993.
• Soriano SG, Logigian EL, Prahl PA, Madsen JR, Scott RM. Nitrous oxide depresses the H-reflex in children with cerebral palsy. American Society for Anesthesiology Meeting abstract, 1994.
• Jackson PS, Strange K, Madsen JR. Identification of volume-sensitive organic osmolyte channels in human glial cells. Society for Neuroscience abstract, 1994.
• Madsen JR, Weisfeiler O, Greenspan A, Benowitz LI. Conditioned media from a transformed glial-like cell line enhances neurite outgrowth and GAP-43 expression. Society for Neuroscience abstract, 1994.
• Medlock MD, Madsen JR, Tarbell NJ, Barnes PD, Anthony DS, Scott RM. The role of surgery in the management of optic chiasm astrocytomas in childhood. American Association of Neurological Surgeons abstract, 1995.
• Madsen JR, Scott RM, Logigian EL. The latency test: criterion for valid reflexes in dorsal rhizotomy surgery. American Society of Pediatric Neurosurgeons abstract, 1995.
• Logigian E, Shefner J, Goumnerova L, Prahl P, Madsen JR. The critical importance of stimulus intensity in intraoperative monitoring for selective dorsal rhizotomy (DR). American Society of Electrophysiology abstract, 1995.
• Madsen JR, MacDonald P, Sankappanavar GH, Benowitz LI. FK-506 improves recovery after spinal cord injury: immunophilins as a new therapeutic target. American Association of Neurological Surgeons abstract, Open Scientific Session, 1996.
• Madsen JR, MacDonald P, Benowitz L. FK-506 improvement in recovery after spinal cord injury: possible role of GAP-43 expression in calcineurin effect. Research Society of Neurological Surgeons meeting abstract, 1996.

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