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Faculty Information

Alexandra J. Golby, M.D.

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Current Research Interests:

My research involves the application of brain mapping techniques to neurosurgical patients. We use multiple functional brain mapping techniques (functional MRI and intracranial EEG) to better understand the cognitive physiology of memory and other higher cognitive functions. The goals are: 1) to use these techniques to define individual functional anatomy in patients with neurosurgical diseases, 2) to cross validate information acquired through different techniques and to gain a better understanding of the relationship between these different brain signals, 3) to demonstrate the anatomical and physiological functional arrangement of specific memory functions, and 4) to demonstrate the ways in which the functional anatomy of memory is altered by disease and recovery. In order to accomplish this, our program includes the following: 1) direct cortical electrophysiologic recording and analysis techniques; 2)advanced functional MR (fMRI) imaging; 3) research methods including data analysis, interpretation, and presentation; and 4) the theoretical underpinnings and investigative tools of current cognitive neuroscience. We perform multi-modality studies of memory- associated cognitive processes in healthy people and neurosurgical patients with epilepsy and brain tumors. This is an extremely rich research environment with numerous collaborators from radiology, engineering, HMS, Brandeis, and MIT.

Teaching Experience:

  • Department of Neurobiology, Stanford University School of Medicine
    Teaching Assistant, Neurobiology and Neuroanatomy. (Jan-March, 1992)

Memberships:

  • Congress of Neurological Surgeons, Resident member
  • American Association of Neurological Surgeons, Candidate member
  • Women in Neurosurgery
  • American Association of Women Surgeons
  • Society for Neuroscience
  • Cognitive Neuroscience Society

Publications:

Abstracts:

  1. Golby AJ, Bush EC, Albers GW. Failure of High-dose Heparin to Prevent Recurrent Cardioembolic Strokes in a Pregnant Patient with a Mechanical Heart Valve. Neurology 1992;42(suppl 3):272.
  2. Heit G, Murphy G, Jaffe R, Golby A, Silverberg G. Effects of Propofol on Human Globus Pallidus Neurons. Stereotact Funct Neurosurg. 1996-97;67:74 (abs).
  3. Golby AJ, Thompson RC, Marks MP, Huhn SL, Steinberg GK. Direct Revascularization in Pediatric Moyamoya Disease. Stroke 1998;29(1):335.
  4. Golby AJ, Poen JC, Adler JR. Three-fraction Stereotactic Radiosurgery for Treatment of Acoustic Neuroma: Tumor control and hearing preservation. 1998 Congress of Neurological Surgeons Annual Meeting, Seattle, WA, October 1998.
  5. Golby AJ, Poen JC, Adler JR. Three-fraction Stereotactic Radiosurgery for Treatment of Acoustic Neuroma: Tumor control and hearing preservation. International Society for Stereotactic Radiosurgery, Sydney, Australia, February 1999.
  6. Golby A, Levin P, Adler J. Stereotactic Radiosurgery for Orbital Tumors: Report of four cases. American Association of Neurological Surgeons, 67th Annual Meeting Poster Program, April 1999.
  7. Golby AJ, Poldrack RA, Spencer D, Brewer JD, Gabrieli JDE. Material- specific lateralization of novelty effects during memory encoding. 29th Annual Meeting-Society for Neuroscience Vol. 25 (1); 646, 1999.
  8. Chiao JY, Golby AJ, Gabrieli JDE, Eberhardt JL. Neural basis of memory differences for same and other race faces. Journal of Cognitive Neuroscience Supplement, April 2000.
  9. Golby AJ, Poldrack RA, Spencer D, Brewer JD, Gabrieli JDE. Material- specific lateralization of novelty effects during memory encoding. American Association of Neurological Surgeons Annual Meeting Scientific Program Book: 102, 2000.
  10. Golby AJ, Poldrack RA, Illes JL, Brewer JD, Shuer LM, Chen DR, Desmond JE, Gabrieli JDE. Novelty-associated mesial temporal lobe activation during memory encoding in patients with mesial temporal lobe epilepsy. 30th Annual meeting-Society for Neuroscience Vol. 26(1); 1244, 2000.
  11. Chiao JY, Golby AJ, Gabrieli JDE, Eberhardt JL. Neural correlates of expertise for same- versus other-race faces. 30th Annual meeting-Society for Neuroscience Vol. 26(1); 282, 2000.
  12. Golby AJ, Silverberg GD, Stebbins GT, Gabrieli JDE. Encoding in Alzheimer's disease: An fMRI study. Journal of Cognitive Neuroscience Supplement, March 2001.
  13. Golby AJ, Silverberg GD, Stebbins GT, Carillo MC, Gabrieli JDE. An fMRI Study of encoding of novel and familiar stimuli in Alzheimer's Disease. 31st Annual meeting-Society for Neuroscience Vol. 27
  14. Golarai G, Golby AJ, Race EA, Chiao JY, Gabrieli JDE, Eberhardt JL. Differential processing of same versus other race faces in object selective fusiform region. Journal of Cognitive Neuroscience Supplement, April 2002.

Book Chapters:

  1. Golby AJ, Adler JR. Stereotactic Neurosurgery. In: A Manual of Surgical Procedures for Anesthesiologists, 2e, Jaffe R, Samuels S, Eds. Lippincott-Raven Publishers, 1998.
  2. Black P, Jaaskelainen J, Chabrerie A, Golby A, Gugino L. Minimalist Approach: Functional mapping. In: Clinical Neurosurgery, Volume 49. Howard, MA III Ed. Lippincott Williams & Wilkins, Philadelphia. 2002
  3. Golby AJ, McConnell KA. Functional Brain Mapping Options for Minimally Invasive Surgery. In: Minimally Invasive Neurosurgery. Black, PM, Proctor M, Eds. In press.

Research Papers:

  1. Portles P, Rojo J, Golby A, Bonnevile M, Gromkowski S, Greenbaum L, Janeway CA, Murphy DB, Bottomly K. Monoclonal Antibodies to Murine CD3e Define Distinct Epitopes, One of Which May Interact with CD4 During T-Cell Activation. Journal of Immunology 1989;142:4169-4175.
  2. Golby AJ, Bush EC, DeRook FA, Albers GW. Failure of High-dose Heparin to Prevent Recurrent Cardioembolic Strokes in a Pregnant Patient with a Mechanical Heart Valve. Neurology 1992;42:2204-2206.
  3. Comess KA, DeRook FA, Beach KW, Lytle, Golby AJ, Albers GW. Transesophageal Echocardiography and Carotid Ultrasound in Patients with Cerebral Ischemia: Prevalence of Findings and Recurrent Stroke Risk. J Am Coll Cardiol. 1994;23:1598-1603.
  4. Golby AJ, McGuire D, and Bayne LL. Neurologic Recovery from Vegetative State Following Cardiac Arrest. Neurology. 1995;45(8):1629-30.
  5. Golby AJ, Bracci PM, Comess KA, DeRook FA, Albers GW. Low Yield of Clinically Significant Transesophageal Echocardiographic Findings in Patients with Lacunar Stroke. J Stroke Cerebrovasc Dis. 1995;5:39-43.
  6. Chan YJ, Golby AJ, Albers GW. Detection of Carotid Stenosis: From NASCET results to clinical practice. Stroke. 1995;26:1325-28.
  7. Golby AJ, Norbash A, Silverberg GD. Trigeminal Neuralgia Resulting from Infarction of the Root Entry Zone of the Trigeminal Nerve. Neurosurgery. 1998;43:620-623.
  8. Golby AJ, Marks MP, Thompson RC, Steinberg GK. Direct and Combined Revascularization in Pediatric Moyamoya Disease. Neurosurgery. 1999; 45:50-60.
  9. Poen JC, Golby AJ, Forster KM, Martin DP, Chinn DM, Hancock SL, Adler JR. Fractionated stereotactic radiosurgery and preservation of hearing in patients with vestibular schwannoma: a preliminary report. Neurosurgery. 1999; 45:1299-1307.
  10. Golby AJ, Poen JC, Forster KM, Martin DP, Adler JR. Three-fraction stereotactic radiosurgery for treatment of vestibular schwannoma in patients with Neurofibromatosis type II. Journal of Radiosurgery. 1999;2:215-221
  11. Golby AJ, Gabrieli JDE, Chiao JY, Eberhardt JL. Differential Responses in the Fusiform Region to Same- and Other-Race Faces. Nature Neuroscience. 2001;4(8):845-850.
  12. Golby AJ, Poldrack RA, Spencer D, Brewer JD, Gabrieli JDE. Material- specific lateralization in the medial temporal lobe and prefrontal region during memory encoding. Brain. 2001;124(9):1841-1854.
  13. Golby AJ, Poldrack RA, Illes J, Brewer JD, Chen D, Desmond JE, Gabrieli JDE. Memory Lateralization in Medial Temporal Lobe Epilepsy Assessed by Functional MRI. Epilepsia 2002;43(8):855-863.
  14. Golby AJ, Silverberg GD, Stebbins GT, Carillo MC, Gabrieli JDE. Memory encoding in Alzheimer's Disease: an fMRI study. Manuscript in preparation.

Presentations and Posters:

  1. 31st Annual Meeting-Society for Neuroscience, San Diego, CA An fMRI study of encoding of novel and familiar stimuli in Alzheimer's Disease. (November 2001)
  2. Congress of Neurological Surgeons, 51st Annual Meeting, San Diego, CA Functional MRI in the Assessment of Memory Lateralization in Medial Temporal Lobe Epilepsy. (October 2001)
  3. Cognitive Neuroscience Society-Annual Meeting, New York, NY Encoding in Alzheimer's Disease: An fMRI study. (March 2001)
  4. 30th Annual Meeting-Society for Neuroscience, New Orleans, LA Novelty-associated mesial temporal lobe activation during memory encoding in patients with mesial temporal lobe epilepsy. (November 2000)
  5. Brigham and Women's Hospital, Harvard Medical School, Boston, MA Functional MRI of memory in healthy and clinical populations. Invited speaker (September 2000)
  6. American Association of Neurological Surgeons-68th Annual Meeting, San Francisco, CA Material-specific lateralization of novelty effects during memory encoding. (April 2000)
  7. Cognitive Neuroscience Society-Annual Meeting, San Francisco, CA Neural Basis of Memory differences for same and other race faces. (April 2000)
  8. 29th Annual Meeting-Society for Neuroscience, Miami, FL Material-specific lateralization of novelty effects during memory encoding. (October 1999)
  9. American Association of Neurological Surgeons-67th Annual Meeting, Stereotactic Radiosurgery for Orbital Tumors: Report of four cases. (April 1999)
  10. San Francisco Neurological Society, 51st Annual Meeting, Aptos, CA Direct and Combined Revascularization in Pediatric Moyamoya Disease. (March 1999)
  11. Congress of Neurological Surgeons, 48th Annual Meeting, Seattle, WA Three-fraction Stereotactic Radiosurgery for Treatment of Acoustic Neuroma: Tumor control and hearing preservation. (October 1998)
  12. American Heart Association, 23rd International Joint Conference on Stroke and Cerebral Circulation, Orlando, FL Direct Revascularization in Pediatric Moyamoya Disease. (February 1998)
  13. Grand Rounds, Division of Infectious Disease, Stanford University School of Medicine, Stanford, CA Accuracy and Interobserver Variation of Clinical Signs in Predicting Degree of Dehydration in Kenyan Children. (June 1994)
  14. Stroke Conference, Departments of Neurosurgery and Neurology, Stanford University School of Medicine, Stanford, CA When is Lacune Really a Lacune? (February 1994)
  15. American Academy of Neurology, Annual Meeting, San Diego, CA Failure of High-dose Heparin to Prevent Recurrent Cardioembolic Strokes in a Pregnant Patient with a Mechanical Heart Valve. (April 1992)
  16. Stroke Conference, Departments of Neurosurgery and Neurology, Stanford University School of Medicine, Stanford, CA Comparison of Angiographic and Ultrasound Measurement of Carotid Stenosis. (April 1991)

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