• 1989-present Stroke, Guest Editor
• 1990-present Journal of Stroke and Cerebrovascular Disease, Guest Editor
• 1991-present Neurosurgery
• 1997-present Operative Techniques in Neurosurgery

Major Research Interests:

1. Clinical: 1. Surgical Treatment of Intracranial aneurysms and other vascular lesions
   2. Skull base exposures to complex vascular lesions and tumors
2. Basic Research: 1. Neuroprotection with estrogens in ischemic and hemorrhagic stroke
   2. Biomarkers of neural injury

Narrative Description of Research

Working in a neuroanatomy laboratory and in the operating room, my clinical research has investigated new and safer surgical approaches to complex tumors and vascular lesions of the skull base. In the lab, I investigate the neuroprotective effects of estrogens against focal and global cerebral ischemia in a rat model. Studies include delivery of the drug before and after the ischemic insult, and the pattern/protection from cell death thereafter. Other projects have investigated intracerebral and subarachnoid hemorrhage, looking at ways to protect nerve cells from irreversible injury following bleeding. We also investigate programmed cell death (apoptosis) in these models, and look at biomarkers that might preceed the actual neuronal death.

Research Funding Information: Past and Present

• 1985-1990 Miles Pharmaceuticals/NIH/Johns Hopkins University (PI) Efficacy Safety Study of Nimodopine in Patients with Subarachnoid Hemorrhage
• 1992-1998 Upjohn Company/NIH/Univeristy of Virginia (PI) Efficacy Safety Study of Tirilazad Mesylate in Patients with Subarachnoid Hemmorrhage
• 1993 NIH/Mayo Clinic, Rochester MN (PI) International Study of Unruptured Intracranial Aneurysms
• 1994-2002 NIH (Co-PI) Ethanol Effects on Neurotransmission
• 1997-1999 University of Florida (Co-PI) Protective Effects of Estrogens Following Cerebral Ischemia
• 1999-2002 US Army Research and Material Command (Co-PI) Neuroprotection from Brain Injury by Novel Estrogens
• 2001 Wyeth-Ayerst (Co-PI) - in preparation for sumission Trial of Premarin for Brain Protection During the Planned Ischemia of Neurosurgery

Principal Clinical and Hospital Service Responsibilities:

• 1977-1978 Instructor, Neurosurgery, University of Florida
• 1978-1983 Assistant Professor of Surgery/Neurosurgery, University of Florida
• 1978-2002 Attending Staff Surgeon, Neurological Surgery, University of Florida Shands Teaching Hospital
• 1978-2002 Consultant, Neurological Surgery, Gainexville VA Hospital
• 1979-2002 Neurosurgeon Consultant, Athletic Department, University of Florida
• 1983-1988 Associate Professor of Neurological Surgery, University of Florida
• 1988-2002 James and Newton Eblen Eminent Scholar in Cerebrovascular Surgery, University of Florida
• 1998-2002 Co-Chairman and Program Director, Department of Neurological Surgery, University of Florida
• 2002-present Professor of Neurosurgery, Harvard University; Associate Chairman and Program Director, Department of Neurosurgery, Brigham and Women's Hospital

Major Administrative Responsibilities:

• 1980-1988 University of Florida, Coordinator of Student and Resident Education
• 1998-2002 Co-Chairman, Program Director
• 1978-2002 Faculty Advisor
• 1980-1989 Surgical Intensive Care Unit Committee
• 1982-1994 Faculty Senate
• 1989 College of Medicine Dean's Search Committee
• 1993 Pathology Search Committee
• 1998 Neuro-Opthalmology Search Committee
• 1990-1993 Medical School Admissions Committee Member
• 1991-1994 Official AMA Medical Schools Representative
• 1995-2002 Brain Institute Committee Member
• 1995-2002 Physician Advisor, Managed Care Committee
• 1995-1997 University of Florida Budget and Finance Committee
• 1998-2002 University of Florida Institutional Committee on Graduate Medical Education

Visiting Professorships / Named Lectureships:

• 1982 Visiting Professor, Republic of China
• 1983 Visiting Professor, University of Cincinnati, Cincinnati, OH
• 1985 Visiting Professor, Harvard University (Massachusetts General Hospital)
• 1986 Visiting Professor, University of Southern California,
• 1986 Visiting Professor, Barrow Neurological Institute, Phoenix, AZ
• 1987 Visiting Professor, Chicago Institute of Neurosurgery and Neuro-Research
• 1987 Visiting Professor, Fukuoka University, Japan
• 1988 Visiting Professor, Columbia University, New York, NY
• 1989 Visiting Professor, Allegheny General Hospital, Pittsburgh, PA
• 1990 Visiting Professor, Cleveland Clinic, Cleveland, OH
• 1990 Visiting Professor, Brazilian Neurosurgical Society
• 1990 Visiting Professor, University of Miami, Miami, FL
• 1992 Visiting Professor, Vanderbilt University, Nashville, TN
• 1993 Visiting Professor, Harvard University (Peter Bent Brigham Hospital)
• 1995 Visiting Professor, University of Texas, Baylor, Houston, TX
• 1995 Visiting Professor, Shinshu University, Japan
• 1996 Visiting Professor, Washington University, St. Louis, MO
• 1996 Visiting Professor, Emory University, Atlanta, GA
• 1996 Visiting Professor, University of Indiana
• 1996 Visiting Professor, Henry Ford Hospital, Detroit, MI
• 1998 Visiting Professor, State University of New York, Buffalo, NY
• 1998 Visiting Professor, University of California, San Francisco, CA
• 1998 Visiting Professor, University of Michigan, Ann Arbor, MI
• 1998 Visiting Professor, University of Nebraska, Omaha, NE
• 2000 Visiting Professor, Hacettepe University, Turkey
• 2000 Visiting Professor, Stanford University, Stanford, CA
• 2001 Visiting Professor, University of Texas Southwestern Medical Center, Dallas, TX

Research Mentorship:

• Joel MacDonald - currently an Assistant Professor at the University of Utah (their CV surgeon); editor of Neurosurgery ON-CALL; Scientific Program Chairman for the Congress of Neurological Surgeons; active in all of organized neurosurgery's (AANS, ABNS, RRC) programs dealing with database processing.
• Francisco Revilla - currently an Associate Professor in Mexico City, and arguably the most well known young vascular neurosurgeon in that country. Scientific Program Chairman for the Mexican and Latin American Neurological Surgery Societies in recent years.
• John Chang - graduate of Montreal Neurologic Institute, now an Assistant Professor at Ohio State University as their CV surgeon
• Michael Cawley - graduate of Emory University, now an Assistant Professor, CV and endovascular surgeon, Emory University in Atlanta.
• Dong Kim - graduate of UCSF, now an Assistant Professor at the University of Texas - Houston and the leading CV surgeon in that city, NIH funded investigator
• Steven Lewis - graduate from Perth, Australia, now an Assistant Professor at the University of Florida as their CV surgeon
• Larry Dickinson - now in private practice in California, formerly the CV surgeon and an Assistant Professor at the University of Michigan
• Robert Mericle now an Assistant Professor at University of Florida as their endovascular surgeon
• Greg Zipfel - chief resident at UF, spent two years with Dennis Choi at Washington University investigating cerebral ischemia; NIH funded; recently accepted CV fellowship at the University of Miami with Roberto Heros; currently writing a book with me on intracranial aneurysms, multiple publications with me as a co- author
• Brad Wallace - a 4th year resident now in his second of three years working on his PhD in Grenoble France, working with Benebid
• Erich Richter - a 3rd year neurosurgical resident, now at University of Toronto working on functional neurosurgery
• Ara Deukmedjian - 5th year resident, recently completed 2-year NIH funded research fellowship in epilepsy at the University of Florida
• Multiple research fellows from the Bejing Neurological Institute, each of whom spent at least two years in my basic science lab at the University of Florida; one is currently at the University of North Texas working on his PhD, and is expected to join the faculty thereafter; another is strategically positioned to become the next chairman of the Bejing Neurologic Institute, perhaps the largest Neurosurgical enterprise in the world.

Bibliography

Original Articles

1. Day AL, Garcia-Bengochea F: Recent Advances in Diagnosis and Treatment of Primary Intracranial Tumors. Journal of the Florida Medical Association 1976; 63:840-843.

2. Day AL, Sypert GW: Spinal Cord Sarcoidosis. Annals of Neurology 1977; 1:79-85.

3. Day AL, Maniscalco JE, Geissinger J, Rhoton AL Jr: Communicating Hydromyelia. Surgical Neurology 1977; 7:157-160.

4. Shuey HM, Day AL, Quisling RG, Sypert GW: Angiographically Cryptic Cerebrovascular Malformations. Neurosurgery 1979; 5:476-479.

5. Jackson RH, Quisling RG, Day AL: Fracture and Dislocation of the Thoracic and Lumbosacral Spine. Neurosurgery 1979; 5:250-253.

6. Day AL: Axioms on Brain Tumors. Hospital Medicine 1980; 16:64-75.

7. Friedman WA, Day AL, Quisling RG, Sypert GW, Rhoton AL Jr: Cervical Carotid Dissecting Aneurysms. Neurosurgery 1980; 7:207-214.

8. Day AL, Rhoton AL Jr, Quisling RG: Resolving Siphon Stenosis Following Endarterectomy. Stroke 1980; 11:278-281.

9. Lister JR, Day AL, Ballinger WB: Ulnar Palsy Caused by Synovial Chondromatosis. Surgical Neurology 1981; 15:428-430.

10. Mickle JP, Menges JT, Day AL, Quisling RL, Ballinger WB: Experimental Aortocaval Fistula in rats. Journal of Microsurgery 1981; 2:283-288.

11. Day AL: Extracranial Intracranial Bypass Grafting in the Surgical Treatment of Bacterial Aneurysms: Report of Two Cases. Neurosurgery 1981; 9:583-588.

12. Day AL: Axioms on Brain Tumors. Tribuna Medica, 1981.

13. Day AL: Brain Tumors: A Clinical Guide. Hospital Medicine 1984; 20:188-216.

14. Day AL: Pathophysiology of Occlusive Stroke Symptoms. American Heart Times, Winter 1981-82.

15. Day AL, Friedman WA, Sypert GW, Mickle JP: Successful Treatment of the Normal Perfusion Pressure Breakthrough Syndrome. Neurosurgery 1982; 11:625-630.

16. Hudgins R, Day AL, Quisling RL, Rhoton AL Jr, Sypert GW: Aneurysm of the Posterior Inferior Cerebellar Artery: A Clinical and Anatomic Analysis. Journal of Neurosurgery 1983; 58:381-387.

17. Kaplan BJ, Day AL, Quisling RG, Ballinger WB: Hemorrhage into Pituitary Adenomas. Surgical Neurology 1983; 20:280-287.

18. Watson RT, Valenstein E, Day AL, Heilman KM: The Effect of Corpus Collosum Lesions on Unilateral Neglect in Monkeys. Neurology 1984; 34:812-815.

19. Day AL: MCA Obstruction: Indications for Surgical Intervention. Journal of Neurosurgery 1984; 60:296-304.

20. Guy J, Savino PJ, Schatz NJ, Cobbs WH, Day AL, Miller NR: Superior Division Paresis of the Oculomotor Nerve. Ophthalmology 1985; 92:777-784.

21. Watson RT, Valenstein E, Day A, Heilman KM: Ablation of Area 7 on Cortex Around the Superior Temporal Sulcus and Neglect. Neurology 1985; 35:179-180.

22. Watson RT, Valenstein E, Day AL, Heilman KM: Normal Tactile Threshhold in Monkeys with Neglect. Neurology 1986; 36:636-640.

23. Day AL, Rhoton AL Jr, Little J: The EC-IC Bypass Study. Surgical Neurology 1986; 26:222-226.

24. Kanter SL, Day AL, Heilman KM, Gonzalez-Rothi LJ: Pure Word Deafness: A Possible Explanation of Transient Deteriorations After Extracranial-Intracranial Bypass Grafting. Neurosurgery 1986; 18:186-189.

25. McVicker J, Day AL, Savage DF, Abela GS, Roberts AJ, Watson RL, Mehta JL: Laser Endarterectomy - A Comparion of Thrombotic Potential Following CO2 Laser vs. Surgical Endarterectomy. Stroke 1986; 17:266-270.

26. Day AL, Savage DF, Friedman WA, Sypert GW: Chemonucleolysis vs. Open Discectomy: The Case Against Chymopapain. Clinical Neurosurgery 1986; 33:385-396.

27. Kaplan BJ, Gravenstein N, Friedman WA, Blackmore JA, Day AL: The Effects of Induced Hypotension During Experimental Vasospasm: A Neurologic, Electrophysiologic and Pathologic Analysis. Neurosurgery 1986; 19:41-48.

28. Day AL, Friedman WA, Indelicato PA: The Treatment of Lumbar Disc Disease in College Football Players. American Journal of Sports Medicine 1987; 15:72-75.

29. Friedman WA, Kaplan BJ, Day AL, Sypert GW, Curran MT: Evoked Potential Monitoring During Aneurysm Surgery-Observations After 50 Cases. Neurosurgery 1987; 20:678-687.

30. Kim LYS, Day AL: The Argon Contact Laser Scalpel: Technical Considerations. Neurosurgery 1987; 21:858-860.

31. Kim LYS, Roxey TE, Day AL: The Argon Contact Laser Scalpel: A Study of its Effects on Atherosclerosis. Neurosurgery 1987; 21:861-866.

32. Ryan PG, Day AL: "Stump" Embolization from the Occluded Internal Carotid Artery: A Case Report. Journal of Neurosurgery 1987; 67:609-611.

33. Onik G Maroon J, Helms C, Day AL, et al: Automated Percutaneous Discectomy: Preliminary Experience. Acta Neurochirurigica 571: Acta Suppl. 1988; 43:58-62.

34. Onik F, Maroon J, Helms C, Schweigel J, Mooney V, Kahanovitz N, Day A, Morris J, McCulloch JA, Reicher M: Automated Percutaneous Discectomy: Initial Patient Experience. Radiology 1987; 162:129-132.

35. Maroon JC, Onik G, Day AL: Percutaneous Automated Discectomy in Athletes. The Physician and Sports Medicine 1988; 16:61-73.

36. Onik G, Mooney V, Maroon J, Wiltse L, Helms C, Schweigel J, Watkins R, Kahanovitz N, Day AL, et al: Automated Percutaneous Discectomy: A Prospective Multi-Institutional Study. JAMA 1988; 43:58-62.

37. Day AL, Salcman M: Subarachnoid Hemorrhage. American Family Physician 1989; 40:95-105.

38. Guy J, Day AL: Surgical Treatment of Progressive Visual Loss in Traumatic Optic Neuropathy. Journal of Neurosurgery 1989; 70:799-801.

39. Guy J, Day AL, Mickle JP, Schatz NJ: Contralateral Trochlear Nerve Paresis and Ipsilateral Horner's Syndrome: A Lesion of the Mesencephalon. American Journal of Ophthalmology 1989; 107:73-76.

40. Guy J, Day AL: Intracranial Aneurysms with Superior Division Paresis of the Oculomotor Nerve. Ophthalmology 1989; 96:1071-1076.

41. Guy J, Day AL: Isolated Trochlear Nerve Paresis Associated with Pituitary Adenoma. Binocular Vision 1989; 4(4):171-174.

42. Day AL: Understanding Brain Tumors. Hospital Medicine 1989; 25:101-123.

43. McVicker JH, Day AL, Seeger JM: Indium Labeled Platelet Deposition Following CO2laser or Surgical Endarterectomy. Laser Surgery: Advanced Characterization, Therapeutics, and Systems 1989; 1066:123-129.

44. Guy J, Johnston PK, Corbett JJ, Day AL, Glaser JS: Treatment of Visual Loss in Pseudotumor Cerebri Associated with Uremia. Neurology 1990; 40:28-32.

45. Day AL: Clinico-anatomic Features of Supraclinoid Aneurysms. Clinical Neurosurgery 1990; 36:256-74.

46. Day AL: Aneurysms of the Ophthalmic Segment: A Clinical and Anatomic Analysis. Journal of Neurosurgery 1990; 72(5):677-691.

47. Onik G, Mooney V, Maroon J, Wiltse L, Helms C, Schweigel J, Watkins R, Kahanovitz N, Day AL, et al: Automated Percutaneous Discectomy: A Prospective Multi-Institutional Study. Neurosurgery 1990; 26(2):228-233.

48. Heilman KM, Bowers D, Watson RT, Day AL, Valenstein E, Hammond E, Duara R: Frontal hypermetabolism and Thalamic Hypometabolism in a Patient with Abnormal Orienting and Retrosplenial Amnesia. Neuropsychologia 1990; 28(2):161-169.

49. Layon AJ, Florete OG, Day AL, James PB, McGuigan JE: The Effect of Duodenojejunal Alimentation on Gastric pH and Hormones in ICU Patients. Chest 1991; 99(3):695-702.

50. Friedman WA, Chadwick GM, Verhoeven F, Mahla M, Day AL: Monitoring of Somatosensory Evoked Potentials During Middle Cerebral Artery Aneurysms. Neurosurgery 1991; 29(1):83-88.

51. Day AL: Aneurysms of the Ophthalmic Carotid Region. Neuroscience Forum 19911(4).

52. Mahla ME, Pashayan AG, Brundy BL, Mixon S, Richards RK, Day AL: Prolonged Anesthesia with Propofal or Isoflurane: Intraoperative Electroencephalographic Patterns and Postoperative Recovery. Sem Anesth 1992; 11 (Suppl):31-36.

53. Scott EW, Day AL, Dolson L, Seeger JM: Carotid Endarterectomy Complicated by Vein Patch Rupture. Neurosurgery 1992; 31:373-377.

54. Day AL: Keeping Neurosurgery Special: The 1993 CNS Presidential Address. Neurosurgery 1994; 34(6):1052-1057.

55. Sulek CA, Mahla ME, Geiser EA, Milburn DJ, Day AL: Cardiovascular Effects of Subarachnoid Hemorrhage, Anesthesiology 1994; 81:A206.

56. Sulek CA, Mahla ME, Geiser EA, Milburn DJ, Day AL: Cardiovascular Effects of Subarachnoid Hemorrhage. Journal of Neurosurgical Anesthesiology 1994; 6:339.

57. Watson RT, Valenstein E, Day AL, Heilman KM: Posterior Neocortical Systems Subserving Awareness and Neglect: Neglect Associated With Superior Temporal Sulcus But Not Area 7 Lesions. Arch Neurol 1994; 51:1014-1021.

58. Heilman KM, Valenstein E, Day AL, Watson R: Frontal Lobe Neglect in Monkeys. Neurology 1995; 45:1205-1210.

59. Moore WS, Barnett HJM, Beebe HG, Bernstein EF, Brener BJ, Brott T, Caplan LR, Day A, Goldstone J, Hobson RW II, Kempczinski RF, Matchar DB, Mayberg MR, Nicolaides AN, Norris JW, Ricotta JJ, Robertson JT, Rutherford RB, Thomas D, Toole JF, Trout HH III, Wiebers DO: Guidelines for Carotid Endarterectomy: A Multidisciplinary Consensus Statement From the Ad Hoc Committee, American Heart Association. Circulation 1995; 91:566-579.

60. Stachniak JB, Layon AJ, Day AL, Gallagher TJ: Craniotomy for Intracranial Aneurysm and Subarachnoid Hemorrhage: Is Course, Cost, or Outcome Affected by Age? Stroke 1996; 27:276-281.

61. MacDonald JD, Day, AL: Surgical Approaches to Aneurysms of the Upper Basilar Artery, in Loftus CM (ed.). Clinical Neurosurgery 1996; 43:127-136.

62. Simpkins JW, Rajakumar G, Zhang YQ, Simpkins CE, Greenwald D, Yu CJ, Bodar N, Day AL: Estrogens May Reduce Mortality and Ischemic Damage Caused by Middle Cerebral Artery Occlusion in the Female Rat. Journal of Neurosurgery 1997; 87: 724-730.

63. Day AL, Cawley M: Stroke: The Neurosurgeon's Domain. Clinical Neurosurgery, 1997; 45:140-145.

64. Zhang Yu-Qi, Shi J, Rajakumar G, Day AL, Simpkins JW: Effects of Gender and Estradiol Treatment on Focal Brain Ischemia, Brain Research 1998; 784: 321-324.

65. Shafron D, Simpkins CE, Jebelli B, Day AL, Meyer EM: Redudcced MK-801 Binding in Neocortical Neurons After AAV-Mediated Transfections with NMDA-R1 Antisense cDNA, Brain Research 1998; 784: 325-328.

66. Shi J, Panickar KS, Yang SH, Rabbani O, Day AL, Simpkins, JW: Estrogen Attenuates Over-Expression of amyloid Precursor Protein Messager RNA in an Animal Model of Focal Ischemia, Brain Research 1998; 810:87-92.

67. Shimohama S, Greenwald D, Kimura J, Shafron D, Akaika A, Maeda T, Kaneko S, Simpkins CE, Day AL, Meyer EM: Nicotinic a7 Receptor Activation Protects Against NMDA-Induced Neurotoxicity and Focal Ischemic Damage in Brain. Brain Research, 1998; 779: 359-363.

68. Crews FT, Steck JC, Chandler LJ, Yu CJ, Day AL: Ethanol, Stroke, Brain Damage, and Excitotoxicity. Pharmacology Biochemistry and Behavior 1998; 59:981-991.

69. MacDonald JD, Antonelli P, Day AL: The Anterior Subtemporal Medial Transpetrosal Approach to the Upper Basilar Artery and Ponto-Mesencephalic Junction, Neurosurgery, 1998; 43(1):84-89.

70. Simpkins JW, Rabbani O, Shi J, Panickar KS, Green PS, Day, AL: A System for the Brain-Enhanced Delivery of Estradiol: An Assessment of Its Potential for the Treatment of Alzheimer's Disease and Stroke, Die Pharmazie 1998; 53 (8):505-512.

71. Hawk T, Zhang Y-Q, Rajakumar G, Day AL, and Simpkins JW: Testosterone Increases and Estradiol Decreases Middle Cerebral Occlusion Lesion Size in Male Rats. Brain Research 1998; 796:296-298.

72. He Z, Yamawaki T, Yang S, Day AL, Simpkins JW, Naritomi H, and Rosenblum WI: An Experimental Model of Small Deep Infarcts Involving the Hypothalamus in Rats: Changes in Body Temperature and Postural Reflex. Stroke, 1999; 12:2743-51.

73. Shi J, Yang SH, Stubley O, Day AL, Simpkins, JW: Hypoperfusion Induces Over-Expression of ??amyloid Precursor Protein mRNA in a Focal Ischemic Rodent Model. Brain Research 2000; 853(1):1-4.

74. Yang SH, Shi J, Day AL, and Simpkins JW: Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult. Stroke, 2000; 3: 745-750.

75. Yang SH, Shi J, Day AL, and Simpkins JW: Estradiol Exerts Neuroprotective Effects When Administered After Ischemic Insult. Stroke, 2000; 3:745-750.

76. Shi J, Bui JD, Yang SH, He Z, Lucas TH, Buckley DL, Blackband SJ, King MS, Day AL, and Simpkins JW: Estrogens Decrease Reperfusion - Associated Cortical Damage: an MRI Analysis in a Transient Focal Ischemia Model. Stroke 2001; 4: 987-992.

77. He Z, Yang SH, Naritomi H, Yamawaki T, Lui QL, King MA, Day AL, and Simpkins JW: Definition of the Anterior Choroidal Artery Territory in Rats Using Intraluminal Occluding Technique. Journal of Neurological Sciences 2000; 182:16-28.

78. Yang SH, He Z, Wu SS, He YJ, Cutright J, Millard WJ, Day AL, and Simpkins, JW: 17-? Estradiol Can Reduce Secondary Ischemic Damage and Mortality of Subarachnoid Hemorrhage. Journal of Cerebral Blood Flow and Metabolism 2001; 2:174-181.

79. Yang SH, Perez E, Cutright J, Liu R, He Z, Day AL, Simpkins JW: Tesotosterone Increases Neurotoxicity of Glutamate In Vitro and Ischemia-Reperfusion Injury in an animal Model. American Physiological Society 2002; 92:195-201.

Proceedings of Meetings

1. VIII International Congress of Neuropathology, Washington, DC, September 1978 "Surface Membrane Redistribution in Experimental Gliomas."

2. International Microneurosurgery Symposium, Boca Raton, Florida, November 1979 "Selection of Patients for Cerebral Bypass Surgery."

3. XIII Chinese Medical Congress and Scientific Meeting, Taipei, Taiwan, July 1981 "Microsurgery and Microneurosurgery."

4. International Congress on Laser Neurosurgery II, Chicago, Illinois, September 1982 "Effects of CO2 Laser on Peripheral Nerve Regeneration."

5. American Heart Association 8th International Joint Conference on Stroke and Cerebral Circulation, San Diego, California, February 1983 "Symptomatic MCA Obstruction: Clinical and Radiographic Features."

6. American College of Surgeons Annual Clinical Congress Cine Program, Atlanta, Georgia, October 1983 "Extracranial to Intracranial Artery Bypass for Cerebral Ischemia."

7. Congress of Neurological Surgeons Annual Meeting, Chicago, Illinois, November 1983 "Symptomatic MCA Obstruction: Indications for Surgical Intervention."

8. Congress of Neurological Surgeons Annual Meeting, New York, New York, October 1984 "Neurosurgical Treatment of Fitness and Sports Injuries" and "EC-IC Bypass: A Fresh Look."

9. Seventh International Symposium on Microsurgical Anastomoses for Cerebral Ischemia, Phoenix, Arizona, October 1984 "EC-IC Bypass for MCA Obstructions."

10. American Heart Association 10th International Conference on Stroke and Cerebral Circulation, New Orleans, Louisiana, February 1985 "Laser Endarterectomy: A Comparison of Thrombotic Potential Following CO2 Laser vs Surgical Treatment."

11. Congress of Neurological Surgeons, Annual Meeting, Honolulu, Hawaii, September 1985 "Management of Intracranial Stenosis" and "The Case Against Chymopapain."

12. American Academy of Orthopaedic Surgery: Sports Medicine Section, Annual Meeting, New Orleans, Louisiana, February 1986 "Observations in the Treatment of Lumbar Disc Disease in College Football Players."

13. Congress of Neurological Surgeons, Annual Meeting, New Orleans, Louisiana, September 1986 "Distal Basilar Aneurysms" and "The Argon Contact Laser Scalpel: A Comparative Study of its Effect on Atherosclerosis."

14. American College of Surgeons, New Orleans, Louisiana, October 1986 "Percutaneous Automated Diskectomy."

15. American Heart Association, 59th Scientific Session, Dallas, Texas, November 1986 "Laser vs. Surgical Endarterectomy in Atherosclerotic Rabbits: Relationship Between Thrombotic Potential and Prostacyclin Biosynthesis."

16. Joint Section on Spinal Disorders, AANS/CNS, Boca Raton, Florida, January 1987 "Treatment of Lumbar Disc Disease in Athletes."

17. American Academy of Neurology 39th Annual Meeting, New York, New York, April 1987 "Pseudotumor Cerebri in Chronic Renal Failure."

18. Xth Mexican Congress of Neurological Surgery, Monterrey, Mexico, July 1987 "Giant Aneurysms," "Natural History of Ruptured Aneurysms," "Posterior Fossa Aneurysms."

19. American Association of Neurological Surgeons Annual Meeting, Toronto, Ontario, April 1988 "Lumbar Spine Injuries in Athletics."

20. Society of University Neurosurgeons Annual Meeting, Tubingen, Germany, July 1988 "Aneurysms of the Ophthalmic Segment."

21. Congress of Neurological Surgeons, General Science Session, Seattle, Washington, September 1988 "Supraclinoid Carotid Aneurysms," "MCA Aneurysms" and "Practical Course on Aneurysms."

22. American Society of Neuroimaging, Annual Meeting, Orlando, Florida, February 1989 "Aneurysms Involving the Cranial Base: Angiography-MRI Correlates."

23. Japanese Congress of Neurological Surgeons, Annual Meeting Fukuoka, Japan, March 1989 "Surgery for Aneurysm of Anterior Circulation," and "Surgical Techniques for Cerebral Aneurysm."

24. American Association of Neurological Surgeons, Washington, DC, April 1989 "Spinal Injuries in Sports," and "Uses of Lasers and Ultrasound."

25. National Medical Association Conference, Orlando, Florida, July 1989 "Management of Aneurysmal Hemorrhage," and "Posterior Circulation Aneurysms."

26. Congress of Neurological Surgeons, Atlanta, Georgia, September,1989. Practical Course Director: Techniques in Aneurysm Surgery, "Carotid Aneurysms," "Intracranial Aneurysms," "Anterior Circulation Aneurysms."

27. 15th International Joint Conference on Stroke and Cerebral Circulation, Orlando, Florida, February 1990 "Surgical Management of Intracerebral Hemorrhage."

28. American Association of Neurological Surgeons, Nashville, Tennessee, May 1990, Practical Course Director: Techniques in Aneurysm Surgery "Carotid Aneurysms"; "The Athlete and the Neurosurgeon"; "Vascular Lesions of the Cavernous Sinus and Paraclinoid Region"; "Visual Loss with Ophthalmic Segment Aneurysms."

29. Brazilian Neurosurgical Society: Port Allegre, Brazil, September 1990 "AVM's of retrosplenial area"; "Management of extracranial cerebrovascular disease"; "Future role of EC-IC bypass"; "Paraclinoid aneurysms"; "Middle cerebral aneurysms"; "The subtemporal approach to basilar apex aneurysms"; "The pterional approach."

30. Congress of Neurological Surgeons, Los Angeles, California, October 1990. Practical Course Director, "Aneurysms" "Microsurgery for aneurysms"; "Difficult decisions in athletics"; Featured speaker, "The role of EC-IC bypass surgery in neurodynamic cerebral ischemia: a surgeon's perspective."

31. Second Annual Meeting of North American Skull Base Society, Lake Buena Vista, Florida, February 1991 "Paraclinoid Aneurysms."

32. American Association of Neurological Surgeons: New Orleans, Louisiana, April 1991, Course Director "Techniques of Surgery of Intracranial Aneurysms"; Moderator: "Improving the Outcome in Aneurysmal SAH"; "Neuroanatomy of Intracranial Surgical Approaches" and "Difficult Decisions in Athletics: Minor Head and Neck Injury"; "Surgical Approaches to Vascular Lesions of the Posterior Circulation"; "Aneurysms of the Middle Cerebral Artery: A Clinical and Anatomical Analysis"; "Pericavernous Aneurysms."

33. Congress of Neurological Surgeons, Marriott World Center, Orlando, Florida, October 1991 "Microsurgery for Aneurysms"; "Sports Injuries in Neurosurgery."

34. Anesthesiology and Critical Care Update, Orlando, Florida, November 1991 "Subarachnoid Hemorrhage - Perioperative Management."

35. Texas Medical Association, San Antonio, Texas, May 1992 "Preoperative Management of the Patient With Ruptured Cerebral Aneurysms in the Anterior Circulation"; "Postoperative Management of Patients with Ruptured Anterior Circulation Aneurysms and Intracranial Hemorrhage."

36. American Association of Neurological Surgeons Annual Meeting, San Francisco, California, April 1992 "Does Age Affect Course and Outcome from Craniotomy for Subarachnoid Hemorrhage?"; "Parieto-Occipital AVMs"; "Vertebrobasilar Aneurysms."

37. Congress of Neurological Surgeons, Washington, DC September1992 "Microsurgery For Aneurysms."

38. American Association of Neurological Surgeons Annual Meeting, Boston, Massachusetts April 1993 "Surgical Techniques in Intracranial Aneurysms: Internal Carotid Artery Aneurysms"; "Complex Aneurysms of the Internal Carotid Artery"; "Aneurysms of the Clinoid Segment"; " Neurosurgery and the Carotid Artery: The Role of the External Carotid Artery."

39. American Heart Association Consensus Conference on Carotid Endarterectomy, Park City, Utah July 1993 "Traumatic Dissection of the Internal Carotid Artery: Conservative vs. Surgical Management."

40. Congress of Neurological Surgeons, Vancouver, Canada, October 1993. Practical Course Co-Director: Techniques in Aneurysm Surgery. Presidential Address: "Keeping Neurosurgery Special."

41. Bascom Palmer Eye Institute 25th Neuro-Ophthalmology Course, Doral Ocean Beach Resort, Miami Beach, Florida December 1993 "Lesions of the Visual Pathways: Proximal Carotid Aneurysms."

42. German and North American Skull Base Societies Joint Annual Meeting, Lake Buena Vista, Florida February 1994 "Vein Bypass Grafts for Skull Base Lesions"; "Management of Parasellar Aneurysms."

43. Japanese Conference on Surgery for Cerebral Stroke Annual Meeting: Kyoto, Japan, March 1994 "Aneurysms of the Parasellar Region, Including New Concepts in the Definition of the Cavernous Sinus."

44. American Association of Neurological Surgeons, San Diego, California, April 1994 "Surgical Techniques in Intracranial Aneurysms"; "Internal Carotid Artery Aneurysms"; "Management of Anterior Circulation Aneurysms"; "Management of Parasellar Region Lesions: Fusiform MCA Aneurysms."

45. Japanese Congress of Neurological Surgeons14th Annual Meeting, Sendai, Japan, May 1994 "Surgical Treatment of Internal Carotid Artery Aneurysms."

46. Surgical Anatomy for Microneurosurgery 8th Annual Meeting, Japan, 1994: "Microsurgical Anatomy of the Craniocervical Junction: Surgical Anatomy."

47. Congress of Neurological Surgeons Annual Meeting, Chicago, Illinois October 1994 "Surgical Techniques in Aneurysm Surgery"; "Management of Vascular Lesions Within the Cavernous Sinus"; "Treatment of Arteriovenous Malformations"; "Anterior Circulation Aneurysms."

48. 22nd Annual Symposium: Recent Advances in Neurology and Neurosurgery, Barrow Neurological Institute, " Phoenix, Arizona March 1995 "Aneurysms of the Clinoid Segment: A Practical Redefinition of Intracavernous Carotid Artery Pathology"; "MCA Dissecting Aneurysms: An Opportunity to Define the Clinical Spectrum of Intracranial Dissections.

49. American Association of Neurological Surgeons Annual Meeting, Orlando, Florida April 1995 "Surgical Techniques in Intracranial Aneurysms"; "Management of Anterior Circulation Aneurysms"; "Management of Aneurysms of the Parasellar Region"; "The Unruptured Aneurysm."

50. Congress of Neurological Surgeons Annual Meeting, San Francisco, California October 1995 "Surgical Approaches to Posterior Fossa Aneurysms"; "Consultants Corner - Cerebrovascular Disease: "Surgical Management"; "Treatment of Intracranial AVMs"; Practical Course: "Anterior Circulation Aneurysms"; "Alterations in NMDA Receptor Concentration in Gerbils Treated with RU40555 Prior to and After a Global Ischemic Insult"; "Does Age Affect Course and Outcome from Aneurysmal Subarachnoid Hemorrhage?"

51. Joint Section on Cerebrovascular Surgery of the American Association of Neurological Surgeons and Congress of Neurological Surgeons Annual Meeting, San Antonio, Texas January 1996: "Anterior Circulation Giant Aneurysms", "Hemodynamics, Atherosclerosis and the Genesis of Intracranial Aneurysms."

52. American College of Surgeons Annual Spring Meeting: New York, New York, April 1996 "Carotid Angioplasty and Stenting."

53. American Association of Neurological Surgeons Annual Meeting, Minneapolis, Minnesota April 1996, " Practical Clinic: Surgical Techniques in Intracranial Aneurysms"; "Variations of the Pterional Craniotomy"; "Neurological Injuries and the Athlete"; "Demonstrating Surgeon: Surgical Dissection: 3-D Video Demonstration."

54. Cerebral Aneurysms and Vascular Malformations-1996 and Beyond, Harvard Medical School Annual Course: Boston, Massachusetts May 1996 "Anterior Circulation Aneurysms", "Clipping Techniques"; "Surgical Management and Results-ICA Aneurysms"; "Small unruptured aneurysms: Surgery."

55. National Athletic Trainers' Association Annual Meeting and Clinical Symposia, Orlando, Florida June 1996: "Examination of the Head and Neck."

56. Joint Third World Stroke Congress and 5th European Stroke Congress, Munich, Germany, September 1996: "Interventional Treatment in Cerebrovascular Disorders."

57. Congress of Neurological Surgeons Annual Meeting, Montreal, Quebec, October 1996 "Anterior Circulation Aneurysms"; "Consultants Corner-Cerebrovascular."

58. Japan Neurosurgical Society Annual Meeting, Toyama, Japan, October 1996: "Ophthalmic Segment Aneurysms"; "Management of Unruptured Intracranial Aneurysms"; "Surgical Approaches to Aneurysms of the Upper Basilar Artery."

59. American Association of Neurological Surgeons Annual Meeting, Denver, Colorado April 1997 Panelist: Proximal Basilar Aneurysms-Coil Vs. Clip; Co-Moderator: Paraclinoid Aneurysms.

60. 1997 Southern Neurosurgical Society, Pinehurst, North Carolina June 1997 Presentation: Long-term Outcomes from Clipping of Basilar Apex Aneurysms; Modern Surgical Results for Non-Basilar Apex Posterior Circulation Aneurysms.

61. National Medical Practice Knowledge Bank Project, Virtual Conference on "Brain Attack," Scottsdale, Arizona May 1997 Presentation: Anterior Circulation Aneurysms.

62. 1997 Florida Medical Association Annual Meeting, Scientific Program, Miami, Florida June 1997 Presentation: Surgical Prevention & Treatment of Stroke.

63. Congress of Neurological Surgeons Annual Meeting,, New Orleans, Louisiana September 1997, "Stroke: The Neurosurgeon's Domain"; "Treatment of Basilar Trunk Aneurysms", Teaching Physicians in University Hospitals: Do They Have a Future? Reimbursement and PATH Issues."

64. Joint Section of Cerebrovascular Surgery Annual Meeting, Orlando, February 1998. "Posterior Circulation Aneurysms."

65. Neurologic Injuries in Athletics Conference, Orlando, Florida, March 1998: "Lumbar Spine Injuries in Athletes."

66. American Association of Neurological Surgeons Annual Meeting, Philadelphia, Pennsylvania April 1998: "Surgical Techniques in Intracranial Aneurysms-Internal Carotid Artery Aneurysms"; "Neurological Injuries and the Athlete"; "Correlative Microvascular Anatomy as a Guide to Better Surgery"; Dramatic Socioeconomic Changes Affecting All Neurosurgeons"; "Anterior Circulation Aneurysms."

67. Endovascular Therapeutic Neuroradiology Workshop & Live Cases, Houston, Texas, October 1998: "Management of Anterior Circulation Berry Aneurysms"; "Management of Posterior Circulation Aneurysms."

68. Joint Section on Cerebrovascular Surgery Annual Meeting, Nashville, Tennessee, February 1999: Special Symposium: Incidental Aneurysms: "Surgical Outcomes: Anterior Circulation Aneurysms." "Skull Base Approaches for Anterior Circulation Lesions."

69. American Association of Neurological Surgeons Annual Meeting, New Orleans, LA, April 1999: "Surgical Techniques in Intracranial Aneurysms"; "Low Back Injuries in the Athlete"; "Posterior Circulation Aneurysms"; "Treatment Algorithms in Complex Intracranial Disease."

70. Congress of Neurological Surgeons Annual Meeting, Boston, MA. October 1999. "Management of Cavernous and Paraclinoidal Vascular Lesions"; "Sports Medicine: What Every Neurosurgeon Needs to Know"; "Sports-related Spine and Spinal Cord Injury."

71. American Association of Neurological Surgeons, Annual Meeting, San Francisco, CA April 2000: "Donaghy Lecture - Paraclinoid Aneurysms: Classification, Natural History, Indications, Methods for Interventions, and Outcomes."; "Surgical Repair of Endovascular Untreatable Cavernous Carotid Aneurysms."

72. Congress of Neurological Surgeons Annual Meeting, San Antonio, TX. September 2000: "Posterior Circulation Aneurysms"; "Management of Cavernous and Paraclinoidal Vascular Lesions"; "Surgical Treatment and Outcomes of Large and Giant Paraclinoid ICA Aneurysms."

73. American Association of Neurological Surgeons, Annual Meeting, Toronto, Ontario April 2001: "Surgical Techniques in Intracranial Aneurysms."; "Management of the Injured Athlete."; "Consultant's Corner: CV."

74. American Heart Association Scientific Session 2001, Anaheim, CA, November 2001: "Oxidant Injury Occurs Rapidly after Global Brain Ischemia and Reperfusion"

Book Chapters and Reviews

1. Day AL, Rhoton AL Jr.: Aneurysms and Arteriovenous Fistulae of the Intracavernous Carotid Artery and its Branches, In Youmans J (ed.): Neurological Surgery, ed. 2. Philadelphia: WB Saunders, 1982, Vol 3, pp 1764-1785.

2. Day AL: Cerebrovascular Disease: A Neurosurgeon's Perspective, In Green BA, Marchall LF, Gallagher TJ (eds): Intensive Care for Neurological Trauma and Disease, New York: Academic Press, 1982, pp 273-292.

3. Day AL: Anatomy of the Extracranial Vessels, In Smith RR (ed.): Stroke and the Extracranial Vessels, New York: Raven Press, 1984, pp 9-22.

4. Day AL: Intracavernous Carotid Artery Aneurysms, In Schmidek HH, Kapp JP (eds): The Cerebral Venous System and its Disorders, Orlando FL: Grune & Stratton, 1984, pp 569-580.

5. Day AL: EC-IC Bypass for MCA Obstructions, In Spetzler, Carter, Selman, Martin (eds): Cerebral Revascularization for Stroke. Thieme-Stratton, Inc., New York, 1985, pp 458-466.

6. Kim L, Day AL: The Contact Laser in Neurosurgery. Neurosurgery: State of the Art Review 2:495-507, 1987.

7. Day AL: Cerebrovascular Anatomy: Arterial Distribution and Variation In Cerebral Blood Flow: Physiologic and Clinic Aspects. Wood HH (ed.), McGraw-Hill, 1987, pp 19-36.

8. Day AL, Savage DF, Friedman WA, Sypert GW: Lumbar Decompression by Chemonucleolysis or Open Discectomy: A Comparison. Lumbar Spine Surgery. Williams & Wilkins, Baltimore, Maryland, 1988, pp 371-378.

9. Day AL, Rhoton AL Jr: Aneurysms and Arteriovenous Fistulae of the Intracavernous Carotid Artery and Its Branches. Chapter 59 In Neurological Surgery, Edition 3, W.B. Saunders & Co., Philadelphia, 1990, pp 1807-1830.

10. Carter RL, Day AL: "Head and Neck Injuries," Chapter 31 In The Team Physicians Handbook. Hanley & Belfus, Philadelphia, 1990, pp 279-288.

11. Day AL, Inoue T, Rhoton AL Jr, Peace D: Microsurgical Anatomy and Surgery of the Paraclinoid Area. In Surgical Anatomy for Microneurosurgery II: Skull Base and Cerebral Veins. Japan, pp 9-16, 1990.

12. Day AL and Chandler HC: Revascularization of Vascular Occlusive Diseases. In Apuzzo MLJ (ed.): Brain Surgery: Complication, Avoidance and Management. New York:Churchill-Livingstone, 1992.

13. Day AL: Ophthalmic Segment Aneurysms. In Rengachary SS (ed.): Neurosurgical Operative Atlas. Baltimore:Williams & Wilkins, 1992.

14. Day AL, Masson RL: Aneurysmal Intracerebral Hemorrhage In Neurosurgery Clinics of North America. Short SC (ed.). Philadelphia:W.B. Saunders Company, 1992.

15. Day AL: Aneurysms of the Ophthalmic Segment, In Wilkins RH & Rengachary SS (eds). Neurosurgery. New York:McGraw-Hill, 1994.

16. Day AL: Keeping Neurosurgery Special: The 1993 CNS Presidential Address, In Loftus CM (ed.). Clinical Neurosurgery, vol. 41. Baltimore:Williams & Wilkins, 1994, pp 1052-1057.

17. Day AL, Masson RL, Knego RS: Surgical Management of Aneurysms and Fistulas Involving the Cavernous Sinus, In Schmidek HH and Sweet WH (eds). Operative Neurosurgical Techniques: Indications, Methods and Results, ed. 3. Philadelphia: W.B. Saunders Company, 1995, pp 975-984.

18. Day AL: Surgical Treatment of Internal Carotid Artery Aneurysms. Proceedings of the 14th Annual Meeting of the Japanese Congress of Neurological Surgeons 14:43-56, 1995.

19. Chandler HC Jr., Day AL: Herniated Nucleus Pulposus in the Athlete, In Menezes AH and Sonntag VH (eds): Principles of Spinal Surgery, vol. 1. New York:McGraw-Hill, Inc., 1996, pp 411-422.

20. Blatt DR, Day AL: Traumatic Dissection of the Internal Carotid Artery: Conservative vs. Surgical Management, In Moore WS (ed.). Surgery for Cerebrovascular Disease, ed. 2. Orlando:W.B. Saunders Company, 1996.

21. Day AL, Morcos JJ, Revilla F: Management of Aneurysms of the Anterior Circulation, In Youmans JR (ed.): Neurological Surgery, Edition 4, vol. 2. Philadelphia:W.B. Saunders Company, 1996, pp 1272-1309.

22. Dickinson LD, Day AL: Surgical Management of the Patient with a Symptomatic Unruptured Aneurysm, In Welch KMA. Primer on Cerebrovascular Disease, San Diego, Academic Press, 1997, pp 462-469.

23. Black S, Sukek C, Day AL: Cerebral Aneurysms and Arteriovenous Malformations, In Cucchiara RF (ed.): Anesthesia and Critical Care. New York:Churchill-Livingstone, 1998, pp. 265-318.

24. Layon AJ, Stachniak JB, Day AL: Neurointensive Care, In Cucchiara RF (ed.): Anesthesia and Critical Care. New York:Churchill-Livingstone, 1998, pp. 557-610.

25. Cawley CM, Zipfel GJ, Day AL, Surgical Treatment of Paraclinoid and Ophthalmic Aneurysms, Neurosurgery Clinics of North America, Vol 9, No. 4, October 1998, pp. 765-783.

26. Day AL, Giovanini MA: Spinal Injuries in Athletes with Cervical Stenosis, Techniques In Neurosurgery, Vol 5, No. 2, June 1999, pp. 185-193.

27. Renfro MB, Day AL, Rhoton AL Jr: The Extracranial and Intracranial Vessels: Normal Anatomy and Variations, In Batjer HH (ed.): Cerebrovascular Disease. New York: Raven Press, 1998, pp. 3-22.

28. Renfro MB, Day AL: Paraclinoid Carotid Aneurysms: Surgical Techniques, In Batjer HH (ed.): Cerebrovascular Disease. New York: Raven Press, 1998, pp. 957-974.

29. Shafron D, Frizzell RT, Day AL: Gene Therapy for Cerebrovascular Disease, In Batjer HH (ed.): Cerebrovascular Disease. New York: Raven Press, 1998, pp. 127-138.

30. Zipfel GJ, Day AL: Tandem Stenotic Lesions of the Cervical Bifurcation and Siphon Regions of the Internal Carotid Artery, In Loftus CM & Kresowik TF (ed.), Textbook of Carotid Artery Surgery, Thieme, 1998, pp. 147-156.

31. Day AL, Cawley CM: Surgical Management of Aneurysms and Fistulas Involving the Cavernous Sinus, Fourth Edition Operative Neurosurgical Techniques, Schmidek and Sweet, 1999, pp. 975-984.

32. Day AL, Kim DH: Surgical Approaches to Terminal Basilar Bifurcation, Posterior Cerebral and Superior Cerebellar Artery Aneurysms, In Kaye AH & Black PM (ed.), Operative Neurosurgery, Churchill Livingstone, 1999, Chapt. 84.

33. Day AL, Giovanini MA: Athletic, Thoracic and Lumbar Spine Injuries, In Cantu R (ed.), Neurological Athletic Head and Spine Injuries, W.B. Saunders, 2001, pp. 167-179.

34. Day AL, Giovanini MA: Lumbar Spine Injuries in Athletes, In Bailes and Day (eds.), Sports Medicine and Neurosurgery, AANS Publications, 2001, pp. 55-65.

Books

1. Bailes JE, Day AL (eds.): Neurological Sports Medicine: A Guide for Physicians and Athletic Trainers, AANS Publications, 2001.

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